Nilotinib attenuates NLRP3 inflammasome activation and GSDMD/NINJ1-mediated pyroptosis via modulation of NF-κB signaling and enhancement of BAG3-dependent aggrephagy and ESCRT-III-mediated plasma membrane repair in microglia.
Microglia are the resident immune cells of the brain and serve as key regulators of innate immune responses within the central nervous system (CNS). The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a multiprotein complex that plays a central role in innate immunity, and its excessive activ...