Mehrdad Shoeibi

Pre-Registered External Evaluation Yields a Consistent Partial-Replication Category across Three Transcriptomic Foundation Models

A pre-registered, final-test-once evaluation framework that locks the outcome rule, seeds, and target-gene-grouped splits before any test data are seen, and scores each frozen representation against a strong expression baseline, a matched-capacity Gaussian control, and a within-split row-identity (shuffle) control.