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Mei-Chen Liu

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Open access Sep 2026

Functional-genomic prioritization identifies MED12 as a candidate RNAi vulnerability in acute myeloid leukemia: evaluation of a T22 peptide-functionalized LNP-siRNA formulation

Background Acute myeloid leukemia (AML) depends in part on transcriptional and epigenetic programs that can be difficult to target with conventional small molecules. RNA interference provides a potential approach to perturb such vulnerabilities, but target selection and intracellular siRNA delivery remain major challen...

Zhou-Chun Chen, Tian-Ran Chai, Mei-Chen Liu et al. · 0 citations

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