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MultiRSF: A Deep Learning Approach for Predicting RNA-Small-Molecule Binding Sites Using Surface Characteristics

Identification of RNA-small-molecule binding sites is a critical first step in RNA-targeted drug discovery. Although several machine learning methods have made progress by integrating RNA sequence, secondary structure, and 3-dimensional (3D) atomic arrangement information to identify nucleotide level binding residues...

Jia-Sai Shu, Wen-Tao Xia, Ying-Jie Zheng et al. · 0 citations
Jul 2026

In Silico Design of High-Affinity Antibody VRC34.01 for HIV-1 Fusion Peptide Recognition.

The broadly neutralizing antibody VRC34.01, isolated from donor N123, recognizes the N-terminal fusion peptide of the HIV-1 envelope glycoprotein gp41 and inhibits viral membrane fusion. A detailed molecular understanding of this interaction is essential for elucidating the basis of peptide recognition and guiding anti...

Mei Feng, Nan Wang, Yi Song et al. · 0 citations

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