Immune ontogeny in childhood-onset systemic lupus erythematosus: effect of immune maturity on disease phenotype and therapeutic responses
Childhood-onset systemic lupus erythematosus (cSLE) occurs during a period of significant developmental changes in the immune system, when tolerance checkpoints and regulatory networks continue to mature. Compared with adult-onset SLE (aSLE), cSLE more frequently presents with strong type I interferon activity, BAFF-in...