Mei Li

PHLDA3 deficiency attenuates neonatal sepsis-associated acute lung injury and is associated with reduced endoplasmic reticulum stress and NF-κB activation.

Neonatal sepsis often causes acute lung injury (ALI), but the underlying molecular mechanisms of ALI have not been elucidated. Pleckstrin homology-like domain family A member 3 (PHLDA3) is a stress-responsive protein involved in inflammatory signaling, yet its role in neonatal sepsis-associated ALI has not been explore...

Olaparib Blocks Oxidative Stress‐Dependent NLRP3 Inflammasome in Pediatric Acute Lung Injury by Metabolic Reprogramming via AMPK‐Driven Autophagic Flux

It is demonstrated that Olaparib ameliorates pediatric ALI through AMPK‐dependent induction of autophagic flux via metabolic reprogramming, attenuating oxidative stress and inhibiting NLRP3 inflammasome activation.

PIP4K2A Attenuates Cerebral Ischemia/Reperfusion Injury by Reducing the TRIB3-p62 Complex Burden and Modulating AKT/mTOR Signaling