Mei-Lin Chen

Functional coupling between MC4R and Kir7.1 contributes to clozapine-induced weight gain in female mice

Most antipsychotic drugs (APDs) cause hyperphagia and weight gain, yet the neural mechanisms underlying these metabolic side effects remain elusive, in part due to difficulties in modeling them in rodents. Here, we establish a mouse model that recapitulates clozapine-induced metabolic syndrome, enabling mechanistic inv...