Mei-Yi Chen

Redox-neutral synthesis of azepane-fused spiroindolenines via Sc(OTf)3-catalyzed cascade [1,5]-hydride transfer/cyclization

Herein, we report the first Sc(OTf)3-catalyzed redox-neutral cascade [1,5]-hydride transfer/cyclization for the efficient synthesis of azepane-fused spiroindolenines. This structurally strained seven-membered-ring scaffold has long eluded efficient access. The reaction proceeds via Knoevenagel condensation, intramolecu...