Mei-Yuan Li

Beyond necroptosis: structural determinants, context-dependent non-canonical functions, and precision therapeutic targeting of RIPK3.

Receptor-interacting protein kinase 3 (RIPK3) is classically recognized as a central executor of necroptosis, but accumulating evidence indicates that its functions extend beyond lytic cell death. RIPK3 regulates metabolic processes, inflammatory signaling, organelle homeostasis, and stress responses through both kinas...