Author

Mei Zhang

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Open access Sep 2026

Versatile Microgel Platform for Intervertebral Disc Degeneration Therapy: Targeting Pericyte‐Mediated Fibrosis and Protecting Nucleus Pulposus Cells

This study identified pericytes as novel fibrotic effector cells in IVDD, contributing to fibrosis through activation of the TGF‐β signaling pathway, and developed a microgel platform designed to specifically inhibit pericyte activation and pro‐fibrotic transition.

Fei Ma, Zhen Zhao, Chuan Guo et al. · Advancement of science · 0 citations

Open access Sep 2026

A dual-targeted oligonucleotide delivery hydrogel for diabetic wound healing: Regulating macrophage-endothelial crosstalk and ferroptosis.

It is demonstrated that this integrated system precisely remodels the pathological immune microenvironment, establishing a promising oligonucleotide-based therapeutic strategy for clinical diabetic wound regeneration.

Mei Zhang, Wen-Bin Yang, Xiao Fu et al. · Journal of Controlled Releas... · 0 citations

Review Open access Aug 2026

ROS-scavenging tetrahedral framework nucleic acids: reprogramming the pathological microenvironment for oral tissue regeneration

This review evaluates how ROS modulate downstream oxidative stress and inflammatory networks to drive tissue destruction and bone metabolic imbalances, and delineates major clinical translation hurdles, including industrial scale-up and pharmacokinetic elimination profiles.

Jia-Hui Xiong, Wu-Xiao Cui, Xiao Fu et al. · Oral Science and Homeostatic... · 1 citation