Author

Meixia Che

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Open access Aug 2026

MBNL1 hijacks a structured single-stranded distal DNA element to sustain FLT3 expression in KMT2A-rearranged leukemias

Findings implicate MBNL1 as a distinct FLT3 activator by recognizing a structured enhancer ssDNA element, highlighting an unexpected role for RNA binding proteins in transcriptional regulation through direct ssDNA recognition.

Meixia Che, Shaela Fields, Siqi Yi et al. · Science Advances · 0 citations