Author

Mélanie Roch

3 papers indexed here

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Open access Sep 2026

Phage heteroresistance in clinical Klebsiella pneumoniae isolates: impact of differentiated capsule expression on phage efficacy

Heteroresistance, commonly described in the context of antibiotics, refers to the presence of resistant subpopulations within a bacterial strain, and is recognized as a likely contributor to treatment failure. Whether population heterogeneity affects phage activity remains poorly understood. We investigated whether...

I. Najjar, Mélanie Roch, Jôiciglecia Pereira dos Santos et al. · Scientific Reports · 0 citations

Open access Aug 2026

Growth-dependent tRNA reprogramming and codon bias link translation to metabolic state in Enterococcus faecalis

ABSTRACT Enterococcus faecalis is a gram-positive commensal bacterium of the human gut microbiome and an opportunistic pathogen responsible for many hospital-acquired infections. Despite the clinical importance of E. faecalis, how gene and protein expression are coordinated with growth remains poorly defined. Here, we...

M. M. Mitchener, Caleb M. Anderson, Mark Veleba et al. · mBio · 0 citations

Open access Sep 2026

Time-resolved transcriptomic analysis reveals envelope stress–mediated adaptation of Escherichia coli to the LPS transport inhibitor thanatin

Gram-negative bacteria are a major cause of antibiotic-resistant infections due to their highly impermeable cell envelope which contains lipopolysaccharide (LPS) and prevents antibiotics from entering the cell. LPS biogenesis relies on the activity of the essential LPS transport machinery (Lpt), which represents an att...

R. Bisht, Elisabete C. C. M. Moura, Julien Prados et al. · Frontiers in Microbiology · 0 citations