Open access
Oct 2026
The modulatory role of early-life experiences and sex on cognitive resilience in APP/PS1 mice over time
BACKGROUND Cognitive resilience to Alzheimer’s disease (AD) can be modelled in amyloid-expressing rodents through early handling (EH). This study investigated how EH and sex affect cognition and pathology over time. METHODS We assessed cognition (open field, object recognition test, Barnes maze) in 6- and 12-month-old...
M. Carrigan, Jeniffer Sanguino-Gómez, Melis Bayer-Var et al.
· bioRxiv · 0 citations