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Author

Melissa A. Boldridge

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Open access Aug 2026

A multi-functional oral small molecule targeting energy and lipid metabolism to treat obesity and related metabolic disorders

Obesity and related metabolic disorders have surged globally, and are mechanistically interconnected through dysregulated energy and lipid metabolism pathways. Current incretin-based obesity treatments act to decrease food intake, but are associated with gastrointestinal side effects and muscle wasting. Here, we identi...

Justin Y. Lee, Chi Zhu, Melissa A. Boldridge et al. · 1 citation
Open access Sep 2026

A positively selected microRNA controls a reversible aging program in striated muscle

Aging is the primary risk factor for most chronic diseases and is characterized in striated muscle by progressive functional decline, mitochondrial dysfunction, and chronic inflammation. The miR-128-1 locus resides within a positively selected haplotype on chromosome 2q21.3 associated with variation in grip strength, p...

Melissa A. Boldridge, Lei Xu, Xiaoyin Wang et al. · 0 citations

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