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Author

Melissa J. Churchill

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Open access Sep 2026

Proteolytic control of the SARS-CoV-2 furin cleavage site defines the phenotypic evolution from the pandemic to endemic state

The successive emergence of SARS-CoV-2 variants with altered tissue tropism has progressively decoupled transmissibility from lower respiratory tract pathogenicity. Omicron lineages transmit exceptionally well whilst limiting severe lung disease. Here, we demonstrate that this phenotype has evolved through two temporal...

A. Aggarwal, S. Ognenovska, Timothy Ison et al. · 0 citations
Review Aug 2026

Quiet but not silent: assessing the impact of intact and defective HIV proviral DNA in the brain.

Defective HIV proviruses make up the majority of the proviral reservoir across blood and tissue compartments and may contribute to chronic inflammation, antigen persistence, and neuropathology in ART-suppressed PWH.

Emily K Chalmers, Janna Jamal Eddine, Liam Yucel et al. · 0 citations

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