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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Melvyn B. Chow

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Jul 2026

Abstract B046: A first-in-class Pin1 degrader provides robust PKPD response and efficacy in PDAC models

A highly selective, first-in-class Pin1 degrader is developed which demonstrated robust PKPD in vivo with sustained target engagement observed following a single dose and it is demonstrated that Pin1 degraders drive significant tumor growth inhibition (TGI) across multiple PDAC efficacy models.

Morgan B. O'Shea, Guo-Sen B. Ye, Melvyn B. Chow et al. · 0 citations
Jul 2026

Abstract B042: Clinical development and mechanism of action of LRK-4189, a first-in-class degrader of the lipid kinase PIP4K2C

Cancer cells maintain their fitness by developing survival adaptations that foster escape from intrinsic and extrinsic mechanisms of cell death in conditions of stress. Phosphatidylinositol 5-phosphate 4-kinase, type II, gamma (PIP4K2C) is a lipid kinase associated with poor outcomes in multiple tumors including...

Krista Goodman, Eva B. d'Hennezel, Morgan B. O'Shea et al. · 0 citations
Jul 2026

Abstract PR011: A first-in-class Pin1 degrader provides robust PKPD response and efficacy in PDAC models

A highly selective, first-in-class Pin1 degrader is developed which demonstrated robust PKPD in vivo with sustained target engagement observed following a single dose and it is demonstrated that Pin1 degraders drive significant tumor growth inhibition (TGI) across multiple PDAC efficacy models.

Morgan B. O'Shea, Guo-Sen B. Ye, Melvyn B. Chow et al. · 0 citations

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