Open access
Sep 2026
Listeriolysin O recruits UBA1 to ubiquitinate NLRP3 and suppress inflammasome defence
The NLRP3 inflammasome is a central cytosolic defence pathway against infection, yet intracellular pathogens must restrain this response to preserve their replicative niche. Here we identify a ubiquitin-dependent immune-evasion mechanism in which L. monocytogenes uses listeriolysin O (LLO) to destabilise NLRP3. The N-t...
Long-Wei Yuan, An Ding, Yu-Chao Feng et al.
· bioRxiv · 0 citations