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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Meng-Chu Sun

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Sep 2026

Metabolic engineering of Saccharomyces cerevisiae for the biosynthesis of indole-derived compounds.

Indole-3-acetonitrile (IAN) and its derivatives-indole-3-carboxaldehyde (I3A), indole-3-carboxylic acid (I3CA), and 3,3'-diindolylmethane (DIM)-are high-value indole-derived compounds widely used in the chemical, pharmaceutical, and nutraceutical industries. However, their de novo microbial production has not yet been...

Meng-Chu Sun, Xiao-Lin Shen, Xin-Xiao Sun et al. · 0 citations
Jul 2026

Microbial Synthesis of Daphnetin by Engineering 2-Oxoglutarate-Dependent Dioxygenases.

Daphnetin is a clinically established coumarin, but its native biosynthetic pathway remains elusive. In this study, a 2-oxoglutarate-dependent dioxygenase (2OGD), AtS8H, was identified that hydroxylates umbelliferone (UMB) to daphnetin , enabling the design of an artificial biosynthetic pathway. However, the pathway ef...

Shunmin Ji, Chong Xie, Yanyan Wang et al. · 0 citations

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