Sep 2026
ACSL5 drives pancreatic ductal adenocarcinoma by suppressing mitophagy and enhancing ferroptosis resistance via the JAK1-STAT1-OASL axis.
It is revealed that targeting mitophagy represents a potential strategy for ACSL5-high PDAC, and its overexpression is significantly associated with shorter patient survival and high diagnostic accuracy, suggesting robust diagnostic potential.
Jing-Jing Dong, Meng-Ting Dai, Yi-Ming Zhou et al.
· Cancer Letters · 0 citations