PhiFold: Towards Dynamic Protein Design with Physics-Structured Covariance Modeling
Protein design is moving beyond structural correctness toward function-aware design, yet existing generative models typically treat dynamics as a downstream property estimated through simulation or prediction after structure generation. Using MD trajectories as a generative target is also undesirable because stochastic...
Yu-Tian Liu, Mu-Jie Lin, Lan-Qian Zhang et al.
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