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Meng-Hua Dong

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Review Open access Sep 2026

WEE1 as a checkpoint regulator and therapeutic vulnerability: From biology to clinical development

WEE1 is a critical cell-cycle checkpoint kinase that inhibits cyclin-dependent kinase activity via phosphorylation, coordinating DNA replication, repair, and mitotic entry. Although primarily recognized for its canonical function at the G2/M checkpoint, WEE1 also modulates S-phase dynamics by preventing unscheduled o...

Hui-Ting Jia, Meng-Hua Dong · 0 citations

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