Meng-Jiang Lu

Neuroimmune activation of the TRPV1–RAMP1 axis drives type 2 immunity to repair intestinal barrier and alleviate metabolic disease

Introduction Obesity is closely associated with intestinal barrier dysfunction and chronic inflammation. Group 2 innate lymphoid cells (ILC2s) can receive and integrate signals from neuropeptides, neurotransmitters, and epithelial cells, thereby regulating local tissue inflammatory responses and promoting repair. Howev...