Meng Li

NQO1‑activated self‑reinforcing bimetallic nanoplatform triggers ferroptosis and cuproptosis for osteosarcoma therapy.

The CFCM/VK3 nanoplatform demonstrates significant tumor suppression and excellent biosafety in an osteosarcoma mouse model, establishing a new paradigm of metal-ion interference therapy that leverages the mutual dependency between iron and copper for self-amplifying antitumor effects.