Meng-Ling Wang

Δ9-tetrahydrocannabinol functions as a G protein-biased dopamine D2 receptor agonist that drives sustained ERK signaling via an EGFR-coupled feed-forward loop.

Δ9-Tetrahydrocannabinol (THC), the principal psychoactive constituent of Cannabis sativa, exerts its central effects predominantly through the cannabinoid CB1 receptor (CB1R). However, molecular mechanisms underlying THC actions beyond canonical CB1R signaling have been suggested but remain incompletely defined. System...