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Open access Sep 2026

Transformer‐Based PET/CT Fusion Enables Preoperative Prediction and Prognostic Stratification of Spread Through Air Spaces in Lung Adenocarcinoma

ABSTRACT Spread through air spaces (STAS) is associated with recurrence and unfavorable outcomes in lung adenocarcinoma, yet reliable preoperative identification remains challenging. This multicenter retrospective study includes 212 patients with 219 tumors across three institutions and develops a transformer‐based mul...

Xin-Yu Zhu, Meng Meng, Zhen-Zhen Wang et al. · 0 citations
Open access Sep 2026

PD-1 deficiency reshapes the TCRβ repertoire and T-cell developmental programs associated with susceptibility to lupus-like autoimmunity

Programmed cell death protein-1 (PD-1) functions as a pivotal immune checkpoint, essential for maintaining peripheral immune tolerance, and serves as a significant therapeutic target in cancer immunotherapy. Nevertheless, the relationship between PD-1 deficiency and baseline alterations in T-cell receptor (TCR) rep...

Xian-Liang Hou, Zhen-Yu Liu, G. Lu et al. · 0 citations

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