Sep 2026
An Orthogonal Framework for Higher-Order Structural and In Vitro Functional Comparability of Chemically Synthesized Liraglutide Relative to an rDNA-Origin Reference Product.
Orthogonal structural and functional characterization can substantially reduce residual uncertainty for synthetic peptide generics referencing recombinant products and provides a practical framework for comparability assessment of complex peptide drugs.
Yang-Ming Tang, Meng-Meng Bai, Xiao-Jie Lu et al.
· Pharmaceutical Research · 0 citations