Meng-Meng Sang

Immunogenic cell death and tertiary lymphoid structures jointly define dysregulated antitumor immune states and therapeutic vulnerability in lung adenocarcinoma

TLS- and ICD-related programs jointly delineate clinically significant immune states in LUAD through convergent transcriptomic, genetic, single-cell, spatial, pharmacological, and systems-level evidence, and are associated with immune microenvironment remodeling, immunotherapy responsiveness, prognosis, and therapeutic...