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Author

Meng-Na Zhang

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2 papers indexed here

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Open access Oct 2026

Structural insights into the ligand modulation of MRGPRX4 conformational plasticity

Chronic pruritus is a debilitating condition with limited treatment options, particularly in cholestatic liver diseases, where bile acid dysregulation is a known trigger. Although Mas-related G protein-coupled receptor X4 (MRGPRX4) has recently been identified as a key mediator of bile acid-induced pruritus, the struct...

Meng-Na Zhang, Yong-Xia Wang, Yun Huang et al. · 0 citations
Sep 2026

Two-Step Design of Triazole-Stapled Opioid Agonists Exhibiting Potent and Prolonged Peripheral Analgesic Activity.

This study establishes a two-step strategy for developing triazole-stapled multifunctional agonists that integrate opioid and neuropeptide FF (NPFF) pharmacophores. Initially, calcium mobilization assays, enzymatic stability tests, and analgesic activity screens identified triazole-stapled opioid peptide 16, derived fr...

Meng-Na Zhang, Jie Gao, Jia-Min Feng et al. · 0 citations

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