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Author

Meng-Yu Li

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2 papers indexed here

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Sep 2026

Substrate-pocket reshaping of an (R)-selective transaminase enables efficient asymmetric synthesis of (R)-3-amino-1-butanol.

(R)-Selective ω-transaminases are valuable biocatalysts for the synthesis of chiral amines and pharmaceutical intermediates, but their practical application is often limited by insufficient catalytic efficiency, poor operational stability and unfavorable reaction equilibrium. Here, an Actinomycete-derived (R)-selective...

Xin-Yu Lu, Feng Guo, Cao-Kai Zhu et al. · 0 citations
Sep 2026

An Enzyme from a Single P450 Monooxygenase Clade Orchestrates Six‑Electron Oxidation for Cyclopeptide Modification

The oxidative modification of complex natural products is critical for their biological activity. However, the enzymatic mechanisms that facilitate three-step, six-electron transfer reactions, such as the conversion of a methyl group to a carboxylic acid, on cyclopeptide scaffolds remain poorly understood. This study...

Ming Peng, Qiao-Ling Wu, Ying-Ying Chen et al. · 0 citations

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