Meng-Yuan Lei

Tumor-associated osteoclasts converge on a matrix-sulfation program across human bone tumors

Introduction Osteoclasts mediate the bone destruction that drives much of the morbidity of giant-cell tumor of bone, osteosarcoma, and skeletal metastasis, yet these large multinucleated cells are lost in droplet single-cell data and have never been defined as a disease cell state. Methods We reanalyzed 378,936 cells f...