Meng-Yun Li

An mPFC-DMV cortical-autonomic-immune axis governs stress-induced immune dysregulation in sepsis.

Chronic psychological stress is a major predisposing factor that worsens sepsis outcomes, yet the neural mechanisms linking stress exposure to immune dysregulation remain poorly understood. Here, using a mouse model of chronic restraint stress (CRS) followed by endotoxemia, we show that prior stress markedly aggravates...