Open access
Oct 2026
Pharmacological inhibition of PRKDC-mediated DNA damage response by 3-hydroxyflavone selectively alleviates MLL-rearranged acute myeloid leukemia
Rearrangements of the mixed lineage leukemia (MLL) gene in acute myeloid leukemia (AML) have been associated with resistance to chemotherapy, and there is currently an unmet clinical need for effective targeted therapies. In this study, we performed high-throughput drug screening and identified 3-hydroxyflavone (3-...
Jing Liu, Chen-Xing Zhang, Min-Yi Zhao et al.
· Cell Death & Disease · 0 citations