Author

Meng Zheng

2 papers indexed here

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Open access Sep 2026

CD73 disruption with tumor-specific CRISPR/Cas9 nanoparticles reduces adenosine-mediated immunosuppression and amplifies response to chemotherapy

The therapeutic efficacy of cancer immunotherapy is impaired by poor tumor immunogenicity and the immunosuppressive tumor microenvironment (TME), partially driven by reprogrammed adenosine metabolism in the tumor. Here, we develop degradable CRISPR/Cas9 nanoparticles to durably and precisely downregulate CD73 expressio...

Xin-Hong Sun, Yu-Jing Sang, Teng-Fei He et al. · Nature Communications · 0 citations

Review Open access Sep 2026

Brain-Targeting siRNA Delivery to Tackle Alzheimer's Disease.

Both the therapeutic promise and the realistic limitations of siRNA-based approaches for AD are discussed, priorities for future development are outlined, and key gaps that must be addressed are identified to enable meaningful clinical implementation.

Qingshan Yang, Zhou-Chun Chen, Jian-Chao Zhu et al. · Wiley Interdisciplinary Revi... · 0 citations