A Biphenyl-Containing Dimeric Sulfonamide PET Tracer for High-Contrast Imaging of Carbonic Anhydrase IX in Clear Cell Renal Cell Carcinoma.
Carbonic Anhydrase IX (CAIX) is an attractive biomarker for clear cell renal cell carcinoma (ccRCC), but small-molecule CAIX radiotracers are often limited by insufficient tumor retention and suboptimal tumor-to-kidney contrast. Herein, we report the rational design of biphenyl-containing bivalent sulfonamide tracers a...