Author

Mengli Wu

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Open access Aug 2026

Single-cell RNA sequencing uncovers an immunosuppressive program in PDAC mast cells: tumour-driven activation, proliferation, and association with Treg recruitment

This study suggests that MCs are key orchestrators of immunosuppression in PDAC, predicted to interact with Tregs through the MIF–CD74/CXCR4 axis, offering a novel rationale for targeting the MC–Treg axis in future immunotherapeutic strategies.

Mengli Wu, Xuxia Ye, Qi Yu et al. · Annals medicus · 0 citations

Open access Aug 2026

Calycosin targets the MAPK-EGR1 signaling axis to inhibit enterovirus 71 replication in cells and human colonic organoids

It is shown that early growth response 1 (EGR1) is independently regulated by each of the three classical MAPK branches including extracellular signal-regulated kinase (ERK), p38 and c-Jun N-terminal kinase (JNK), and serves as a common downstream target of these pathways to promote EV71 replication and virus-induced c...

Yue Liu, Jiale Wang, Xin Chen et al. · Virulence · 0 citations