Merja R. Häkkinen

Adrenal androgens, estrone, and insulin-like growth factor 1 are associated with thelarche without gonadotropin activation in girls.

INTRODUCTION Although a well-known phenomenon, the hormonal mechanism of thelarche in the absence of gonadotropin activation remains unclear. To reveal the biological mechanisms of such thelarche we assessed serum concentrations of several hormones potentially related to breast development, as well as clinical signs of...