Codelivery of nivolumab and Galunisertib by EGFR-targeted spherical polymeric nanoparticles for effective treatment of non-small cell lung cancer.
A novel nanosystem was developed by co-loading galunisertib, a TGF-β inhibitor, and nivolumab into spherical nanoparticles composed of PLGA derivatives conjugated with anti-EGFR for targeted delivery that maintained antitumor activity comparable to the free-drug combination while enabling tumor-directed delivery and sh...