Author

Mesut Işık

4 papers indexed here

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Open access Sep 2026

Assessment of Antioxidant Capacity, Phytochemical Phenolic Composition, Cholinesterase and α-Glucosidase Inhibitory Activities, and Antimicrobial Potential of Tribulus terrestris

Tribulus terrestris (TT) is a medicinal plant traditionally utilized in the management of various health conditions, including inflammation, edema, and hypertension. The present study aimed to investigate the phenolic profile of the ethanolic extract of TT and to evaluate its antioxidant, antimicrobial, anticholinester...

A. Ndhlala, Emrah Dikici, Sevgi Altın et al. · Molecules · 0 citations

Open access Oct 2026

Design and Synthesis of New Thiazole Derivatives for Alzheimer’s Disease Therapy as a Potential Cholinesterase Inhibitor; Toxicity Prediction and Molecular Docking Studies and Biological Evaluation

In this study, thiazole derivatives 13–23 were synthesized as novel cholinesterase inhibitors. Their structures were elucidated using 1H-NMR, 13C-NMR, and elemental analysis techniques. The binding positions and efficiencies of the designed compounds on the enzyme were investigated through molecular docking studies, an...

Mesut Işık, Gresa Halimi Syla, Abdüllatif Karakaya et al. · Molecules · 0 citations

Open access Sep 2026

Phytochemical Phenolic Profile, Cholinesterase and α-Glucosidase Inhibitory Activities Rationalized by Molecular Docking, and Antioxidant Capacity of Hibiscus sabdariffa

This study aimed to evaluate the antioxidant, anticholinesterase, and α-glucosidase (AG) inhibitory activities of the ethanolic leaf extract, characterize its phenolic composition, and investigate the interactions of the major identified phytochemicals with the target enzymes through molecular docking analysis. The phe...

A. Ndhlala, Emrah Dikici, Sevgi Altın et al. · Molecules · 0 citations

Open access Jul 2026

Design, Synthesis, In Silico ADME, Toxicity Prediction and Molecular Docking Studies of Benzimidazole-Oxadiazole Derivatives for α-Glucosidase and Aldose Reductase Pathways as Potent Anti-Diabetic Agents

Overall, the newly synthesized compounds demonstrated pronounced AR inhibitory activity and notable α-GLY inhibition and may therefore be considered potential candidates for further investigation as anti-diabetic agents.

Mesut Işık, Abdüllatif Karakaya, U. A. Çevi̇k et al. · Molecules · 0 citations