Mian T. Mhindu

Targeting GPX4 and FSP1 to exploit ferroptotic vulnerability in Ewing sarcoma

Ewing sarcoma tumors are defined by chromosomal translocations fusing EWSR1 to ETS family genes, most commonly FLI1 . The resulting EWS::FLI1 fusion oncoprotein drives tumorigenesis while simultaneously generating unique metabolic and molecular dependencies that may be exploited for Ewing sarcoma–specific therapi...