Author

Mianzhi Pan

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Open access Jul 2026

Strict OOD Antigen-to-Antibody Retrieval with CDR-Aware Slot Late Interaction

CASLR is proposed, an antibody CDR-aware slot late-interaction retriever that encodes antigens with ESM-2, encodes antibodies with IgBert, constrains antibody-side latent slots to complementarity-determining regions (CDRs), and scores local slot compatibility instead of single-vector global similarity.

Peishuo Liu, Mianzhi Pan, Chenyang Yan et al. · bioRxiv · 0 citations