Author

Miao-Jin Zhou

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Aug 2026

FOCUS: A Dual-Mismatch crRNA Strategy Unlocks High-Fidelity One-Step SNV Detection with Cas12a.

CRISPR/Cas12a has emerged as a powerful tool for nucleic acid detection; however, its clinical utility is severely hampered by intrinsic limitations in single-nucleotide variant (SNV) discrimination, reliance on pre-processed single-stranded DNA (ssDNA) templates, and cumbersome multi-step workflows. Here, we report a...

Miao-Jin Zhou, K. Du, Mingjun Jiang et al. · ACS Sensors · 0 citations

Review Open access Jul 2026

Advances in Research on AARS1/AARS2-Related Disorders: A Focus on Leukodystrophies

Leukodystrophies (LDs), a group of heterogeneous genetic disorders, are characterized by selective involvement of cerebral white matter, including abnormal white matter development and/or progressive degeneration. Oligodendrocytes, astrocytes, microglia, axons, and the neurovascular unit collectively contribute to whit...

Zhen-Yu Yang, Wendiao Zhang, Fengyi Yu et al. · Genes · 0 citations