Background: Cancer cells frequently acquire adaptive resistance to targeted therapies; however, strategies capable of concurrently overcoming treatment tolerance and reactivating cell death pathways are currently lacking. Here, we investigated the dual role of ferredoxin 1 (FDX1) in modulating both multikinase inhibito...
Wei-Kai Wang, Xin Jiang, Xiaona Chen et al.· Cancer Communications· 0 citations
ABSTRACT p62/SQSTM1 is a multifunctional adaptor protein that serves as a central hub integrating cellular stress responses, including selective autophagy, antioxidant defense, metabolism, and immune signaling. Its diverse functions are precisely orchestrated by a complex network of posttranslational modifications (PTM...
Breast cancer (BC) persists as a leading cause of cancer-related mortality among women globally. While the characterization of molecular subtypes has improved our understanding and precision treatment of the disease, the detection and analysis of circulating tumor cells (CTCs) offer a complementary, dynamic perspective...
Chentao Li, Miaoqin Chen, Zhuo Wang et al.· Biochimica et biophysica act...· 0 citations
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