Open access
Sep 2026
Malic enzyme 1 senses L-lactate to determine tumor heterogeneity
L-lactate is generally elevated in tumors and acts as a signaling molecule that promotes tumor progression. Here, we reveal that malic enzyme 1 (ME1) functions as a previously unrecognized sensor of L-lactate through direct binding at arginine 155 (R155), thereby potentiating malignancy. Mechanistically, L-lactate bind...
Si-Yi Cao, Kewen Hu, Shi-Jing Huang et al.
· Signal Transduction and Targ... · 0 citations