Comparative Investigation of Immunopathogenesis in HIV-and Mycobacterium Tuberculosis Single Infection Versus Co-Infection Using Humanized Mice
Miao-Yun Zhao, Subhur Mandal, Yi-Lun Cheng et al.
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Open access
Aug 2026
A TCR-mimic bispecific antibody reduces HIV-1 provirus and delays viral rebound in HLA-matched humanized mice.
In vivo evidence is provided that a peptide-HLA-directed bispecific antibody can both shrink the intact HIV reservoir and defer viral recrudescence, supporting further development of TCR-mimic bispecific antibodies for cure strategies.
Zhe Yuan, N. Board, Miao-Yun Zhao et al.
· Proceedings of the National... · 0 citations