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Michael A. Cianfrocco

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Open access Oct 2026

Taccalonolide AJ uncouples tubulin GTP hydrolysis from microtubule depolymerization

Microtubules are dynamic polymers of tubulin subunits that are vital for a variety of eukaryotic cell functions, including intracellular trafficking and cell division. Microtubule-targeting drugs are among the oldest and most widely used chemotherapeutics. Despite their extensive use, the development and optimization o...

Ezekiel C. Thomas, Nicholas E. Vangos, Lauren A. McCormick et al. · 0 citations

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