Author

Michael Amling

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Open access Sep 2026

Multiscale assessment of glucocorticoid-induced alterations across bone marrow and mineralized bone in human iliac crest biopsies.

BACKGROUND Glucocorticoid-induced osteoporosis (GIOP) is associated with a fracture risk that exceeds what would be expected based on bone mineral density (BMD) alone, suggesting impaired bone quality. In contemporary clinical practice, patients receiving glucocorticoids are typically treated concomitantly with anti-os...

P. Sihota, Xenia Junimann, Johannes Krug et al. · Journal of Bone and Mineral... · 0 citations

Open access Sep 2026

Skeletal pathologies caused by PLS3 inactivation are predominantly associated with impaired cortical bone integrity.

The identification of pathogenic PLS3 variants in individuals with X-linked osteoporosis (XLO) has demonstrated the importance of the actin-bundling protein plastin-3 for skeletal integrity. We and others have previously reported that Pls3-deficient mice display a skeletal phenotype that unexpectedly affects only the c...

O. Windels, A. Simon, Lara Schiewek et al. · Journal of Bone and Mineral... · 0 citations

Open access Jul 2026

Atypical Femoral Fractures in Adult Patients with Classical Osteogenesis Imperfecta

Atypical femoral fractures (AFF) are rare fractures with characteristic radiographic features, most commonly associated with long-term bisphosphonate use. Their occurrence in patients with osteogenesis imperfecta (OI), a hereditary bone disease leading to bone fragility, is not well understood. In this study, 138 adult...

Mikolaj Bartosik, O. Windels, F. Barvencik et al. · Calcified Tissue Internation... · 0 citations