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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Michael B. Dwinell

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2 papers indexed here

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Sep 2026

Abstract A116: Mito-Met10 remodels the pancreatic tumor microenvironment through MAVS activation and CD8+ T cell metabolic reprogramming

Pancreatic ductal adenocarcinoma is characterized by an immune-excluded tumor microenvironment that limits responsiveness to immunotherapy. Because mitochondrial metabolism regulates both tumor cell survival and immune cell function, mitochondria-targeted therapies may simultaneously induce tumor cell death and r...

Maria Poimenidou, Mahmoud A. Eid, Joanna Le et al. · 0 citations
Sep 2026

Abstract B079: Comprehensive expression atlas of chemokine ligands and receptors reveals endothelial ACKRs as regulators of immune exclusion in human PDAC

Pancreas cancer remains a devastating disease with an immunologically cold microenvironment that resists immunotherapies. Because immune cell recruitment is dependent on chemokine signaling, clinical trials targeting chemokine receptors have shown limited benefit due to signaling redundancy. We hypothesized that the...

Ayush Bharati, Donovan Drouillard, Maria Poimenidou et al. · 0 citations

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