Author

Michael Brimacombe

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Review Open access Sep 2026

Prior Density Selection and Statistical Models

In the application of Bayesian methods, the choice of a prior density for defined model parameters is often a practical issue. In scientific and medical applications, it requires careful justification. In many settings, the properties of the statistical likelihood function and the overall statistical model, within whic...

Michael Brimacombe · Stats · 0 citations

Review Open access Aug 2026

The Oxidative Stress and Inflammatory Metabolic Pathways of Some Environmental Toxicants Inflicting Human Disorders

The cell and molecular events induced by some diverse toxicants are reviewed, along with their potential additive, synergistic, and antagonistic effects on immune homeostasis (increasing proinflammatory immune cell activation and suppressing immunoregulation), which leads to systemic oxidative stress (OS).

Michael Brimacombe, David A. Lawrence · Toxics · 0 citations