Author

Michael O'Donovan

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Open access Jul 2026

Polygenic associations with phenotypic classes across the psychosis-affective spectrum

Introduction Limitations of current classifications of schizophrenia, schizoaffective disorder, and bipolar disorder are evident from their overlapping symptoms, aetiologies, treatments, and outcomes, and present a barrier to novel treatment discovery. Alternative conceptualisations are needed to address nosological va...

Charlotte A. Dennison, S. Legge, A. Cardno et al. · medRxiv · 0 citations

Open access Aug 2026

The association of schizophrenia polygenic scores with continuously-hospitalized, treatment-resistant schizophrenia.

A greater burden of common genetic variants is associated with more severe forms of illness in schizophrenia.

Urmi Das, J. Crowley, R. Karlsson et al. · Molecular Psychiatry · 0 citations

Open access Aug 2026

Integrating biological pathway polygenic scores and trauma in psychosis: findings from the EU-GEI study

Findings provide proof-of-concept for the utility of pPGSs in psychiatric research, suggesting both genetic contributions to trauma exposure and GxE effects on psychosis risk, as well as supporting pathway-specific contributions beyond general polygenic risk.

G. Trotta, I. Austin-Zimmerman, E. Spinazzola et al. · Translational Psychiatry · 0 citations

Open access Aug 2026

Prolonged Childhood and Adolescent Loneliness in First-Episode Psychosis: Synergistic Polygenic Effects and Functional Outcomes.

Prolonged CAL is linked to higher risk of FEP, preferentially affective psychosis in females, poorer functioning, and developmental potentiation of polygenic liability.

Á. Andreu-Bernabeu, J. González-Peñas, M. Bernardo et al. · Schizophrenia bulletin · 0 citations