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Author

Michael J. Gebhardt

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Open access Sep 2026

Actuation of CRP activating region 3 by formylation modulates the Vibrio cholerae response to oxidative DNA damage

The cyclic AMP receptor protein or CRP is a global regulator of bacterial metabolism. CRP activates transcription of genes required for utilization of alternative carbon sources in response to the second messenger cAMP, which is synthesized in the setting of glucose scarcity. Transcription is activated through contact...

Renato E. R. S. Santos, Pallabi Basu, Brendan J. O'Hara et al. · 0 citations
Open access Sep 2026

Loss of CsrA in Acinetobacter baumannii leads to lethal dysregulation of alanine metabolism

Significance In the pathogen Acinetobacter baumannii, the posttranscriptional regulator CsrA is required for growth under certain environmental conditions, including rich growth media and infection-relevant conditions like human serum. However, CsrA is dispensable for A. baumannii grown under nutrient limited condition...

Rosa L. Sava, Michael J. Gebhardt · 0 citations

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